Although individuals infected with human immunodeficiency virus HIV seem to be more infectious in the late stages of HIV infection and possibly also during the seroconversion period, most estimates of per-sexual-contact infectivity have been obtained without allowing for variability over the course of infection. In this analysis, a probabilistic model was fitted to data from a European study carried out between and that involved males and females HIV-infected subjects index cases and their regular heterosexual partners. Indeed, the results for penile-anal sex suggest that persons who are in the process of seroconverting may be much more infectious than asymptomatic infected persons, whatever the type of contact. Prevention education should stress the risk of HIV transmission from subjects who may be unaware of their infection. Abstract Although individuals infected with human immunodeficiency virus HIV seem to be more infectious in the late stages of HIV infection and possibly also during the seroconversion period, most estimates of per-sexual-contact infectivity have been obtained without allowing for variability over the course of infection.
Heterosexual Transmission of Human Immunodeficiency Virus
Heterosexual Transmission of HIV | JAMA | JAMA Network
To the Editor. The observed case was in a couple described as unique in that vaginal and penile bleeding during intercourse was noted. On the other hand, male-to-female transmission was estimated to be De Vincenzi I. Heterosexual Transmission of HIV. Coronavirus Resource Center. All Rights Reserved.
Heterosexual transmission of human immunodeficiency virus infection – Strategies for prevention
Few issues related to acquired immunodeficiency syndrome AIDS have generated as much interest and debate as heterosexual transmission of human immunodeficiency virus HIV and its potential contribution to maintenance and growth of the epidemic. Some have suggested that the growing interest in heterosexual transmission has prejudicial elements, that funding for research and control of AIDS depends on its impact on "us" more than the welfare of "them. Moreover, the modes of transmission and the populations at risk are distinguished not by sharp lines but by broad shades of gray.
Researchers conducting a meta-analysis of studies of the risk of HIV transmission during heterosexual sex have found that, in high-income countries prior to the introduction of combination therapy, the risk per sexual act was 0. However, these rates were considerably higher in lower-income countries, if the source partner was in either the very early or the late stage of HIV infection, or if one partner had genital ulcer disease, write the researchers in the February issue of The Lancet Infectious Diseases. Marie-Claude Boily and colleagues attempted to identify all relevant observational studies of a sufficient methodological quality that provided empirical estimates of the transmission risk per sexual act rather than the cumulative risk during an ongoing relationship with an HIV-positive person. Looking for material on HIV-1 only, they found 43 relevant publications covering 25 different study populations.