Cocaine and sex

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Crack cocaine use disorder CUD has been related to sex differences. This work aimed to compare the severity of drug use and the severity of other negative related outcomes in males and females with CUD. A total of inpatients males and females with crack cocaine use disorder CUD were evaluated by a detailed multidimensional clinical assessment, including addiction severity and trauma exposure. Females had higher rates of other mental disorders, particularly trauma and stress-related disorders OR: 3. Important sex differences also emerged in trauma history and HIV infection prevalence. CUD has a more severe clinical presentation among females facing early abstinence.
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Cocaine And Sex: The Effects Of Cocaine On Sex Drive

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Get the latest information from CDC coronavirus. Women report more intense highs from cocaine than men do, and they become addicted to the drug more rapidly. Studies have shown that the female hormone estradiol contributes to these differences, but not how. New NIDA-supported research supplies a possible answer. The Minnesota researchers demonstrated that specifically in female rats, estradiol activates the mGluR5 and the cannabinoid receptor CB1R signaling pathways, resulting in heightened behavioral responses to cocaine.
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Although cocaine use has been linked to sexual HIV risk behavior for decades, the direct effects of cocaine on sexual desire and sexual decision-making are unexamined. Research suggests delay discounting devaluation of future outcomes and probability discounting devaluation of uncertain outcomes play roles in condom use decisions. This study examined the effect of cocaine administration on sexual desire, hypothetical condom use, and discounting tasks. Measures included sexual desire and other subjective ratings, the Sexual Delay Discounting Task, the Sexual Probability Discounting Task, and monetary delay and probability discounting tasks. Cocaine caused dose-related increases in sexual desire and prototypical stimulant abuse-liability ratings.
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