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The two main defects of mice homozygous for the nude spontaneous mutation Foxn1 nu , formerly Hfh11 nu are abnormal hair growth and defective development of the thymic epithelium. Nude mice are also athymic; homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. Homozygous nude mice show partial defect in B cell development. Although the mice appear hairless, they are born with functional but faulty hair growth follicles.
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Metastatic behavior of human tumor cell lines grown in the nude mouse

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A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus , resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype main outward appearance of the mouse is a lack of body hair, which gives it the "nude" nickname. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. These xenografts are commonly used in research to test new methods of imaging and treating tumors. The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene.
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